- Table of Content
The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is included in overall mRNA turnover and especially degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.
|RNase PH family|
|Sequence:||13; NC_000013.11 (37000373..37009614)|
Cytoplasm. Nucleus. Nucleus, nucleolus.