Eyes absent homolog 4 (EYA4)

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and functions as a mark that distinguishes between apoptotic and repair responses to genotoxic stress.

Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its role as histone phosphatase probably explains its role in transcription regulation during organogenesis.