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- Table of Contents
Separin Antibodies
AND ESPL1 ELISA kits, Separin Proteins
Many biological assays use antibodies to detect Separin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Separin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Separin antibodies...
Designing an IHC experiment for Separin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ESPL1 IHC GuideESPL1 Infographic by Boster Bio
All ESPL1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$540
Cat # EKC2000
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2000
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1516
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1516
1 kit, containing one 96-well plate and all necessary reagents
ESPL1 Overview
Facts about Separin.
Separin (ESPL1)
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | ESPL1 |
| Uniprot: | Q14674 |
| Entrez: | 9700 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Caspase-like protein ESPL1; EC 3.4.22.49; ESP1extra spindle poles like 1; extra spindle pole bodies homolog 1 (S. cerevisiae); extra spindle poles like 1 (S. cerevisiae); Extra spindle poles-like 1 protein; FLJ46492; KIAA0165separin; Separase
Molecular Weight
Mass (kDA):
233.175 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.13 |
| Sequence: | 12; NC_000012.12 (53268257..53293643) |
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Aneuploidy
- Cell Transformation, Neoplastic
- Haploinsufficiency
- Leukemia
- Metastatic Malignant Neoplasm To The Lymph Node
- Adult Acute Myeloblastic Leukemia
- Thymus Neoplasms
- Sarcoma
Pathways
- Mitosis
- Spindle Checkpoint
- Anaphase
- System Development
- Cell Cycle
- Nervous System Development
- Metaphase
- Central Nervous System Development
PTMs
Research Areas
- Apoptosis
- Cancer
- Cell Biology
- Cell Cycle and Replication
- Cellular Markers
- Chromatin Research
- DNA Repair
- Mitotic Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ESPL1
bosterbio.com/bosterbio-gene-info-cards/ESPL1
References
PMID: 12194817 by Waizenegger I., et al. Regulation of human separase by securin binding and autocleavage.
PMID: 10411507 by Zou H., et al. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis.