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- Table of Contents
Facts about Extracellular serine/threonine protein kinase FAM20C.
Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a wider substrate specificity (PubMed:26091039). Phosphorylates casein as well as a variety of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606).
| Human | |
|---|---|
| Gene Name: | FAM20C |
| Uniprot: | Q8IXL6 |
| Entrez: | 56975 |

| Belongs to: |
|---|
| FAM20 family |

dentin matrix protein 4; DKFZp547C074; DMP4; DMP-4; FAM20C; family with sequence similarity 20, member C; GEF-CK; RNS
Mass (kDA):
66.234 kDA

| Human | |
|---|---|
| Location: | 7p22.3 |
| Sequence: | 7; NC_000007.14 (192571..260772) |
Widely expressed.
Secreted. Golgi apparatus.





PMID: 15676076 by Nalbant D., et al. FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells.
PMID: 22582013 by Tagliabracci V.S., et al. Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.