Tumor necrosis factor receptor superfamily member 6 (FAS)

Receptor for TNFSF6/FASLG.

The adapter molecule FADD recruits caspase-8 to the activated receptor.

The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of older T-cells, or both.