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- Table of Contents
Facts about Filamin-binding LIM protein 1.
May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly.
Human | |
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Gene Name: | FBLIM1 |
Uniprot: | Q8WUP2 |
Entrez: | 54751 |
Belongs to: |
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No superfamily |
CAL; DKFZp434G171; FBLP-1FBLP1CSX-associated LIM; filamin binding LIM protein 1; filamin-binding LIM protein 1; filamin-binding LIM protein-1; MIG2-interacting protein; migfilin; mitogen-inducible 2 interacting protein; Mitogen-inducible 2-interacting protein
Mass (kDA):
40.67 kDA
Human | |
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Location: | 1p36.21 |
Sequence: | 1; NC_000001.11 (15756170..15786590) |
Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets.
Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber. Associated with actin stress fiber at cell-ECM focal adhesion sites (PubMed:12679033, PubMed:18829455). Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2 (PubMed:12679033). Isoform 2 is localized at actin stress fibers (PubMed:12496242).
PMID: 12679033 by Tu Y., et al. Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation.
PMID: 12496242 by Takafuta T., et al. A new member of the LIM protein family binds to filamin B and localizes at stress fibers.