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Fibulin-5 Antibodies
AND FBLN5 ELISA kits, Fibulin-5 Proteins
Many biological assays use antibodies to detect Fibulin-5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Fibulin-5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Fibulin-5 antibodies...
Designing a Western blot for Fibulin-5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FBLN5 Western Blot GuideFBLN5 Infographic by Boster Bio
All FBLN5 Products
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FBLN5 Overview
Facts about Fibulin-5.
Fibulin-5 (FBLN5)
Essential for elastic fiber formation, is involved in the fabrication of constant elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and arouses elastic fibers in the skin, lung and vasculature (By similarity).
Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which might play a role in vascular development and remodeling (PubMed:10428823).
Gene Information
| Human | |
|---|---|
| Gene Name: | FBLN5 |
| Uniprot: | Q9UBX5 |
| Entrez: | 10516 |
Family
| Belongs to: |
|---|
| fibulin family |
Alternative Names
ARMD3fibulin-5; DANCE; DANCEFIBL-5; Developmental arteries and neural crest EGF-like protein; EVEC; FBLN5; Fibulin 5; UP50; UP50FLJ90059; Urine p50 protein
Molecular Weight
Mass (kDA):
50.18 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.12 |
| Sequence: | 14; NC_000014.9 (91869411..91947702, complement) |
Tissue Specificity
Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed:10428823).
Subcellular Localizations
Secreted. Secreted, extracellular space, extracellular matrix. co-localizes with ELN in elastic fibers.
Diseases
- Cutis Laxa
- Neoplasms
- Blepharoptosis
- Tissue Adhesions
- Tumor Angiogenesis
- Pelvic Organ Prolapse
- Age Related Macular Degeneration
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Cell Invasion
- Uterine Prolapse
- Neoplasm Metastasis
Interacting Proteins
- EFEMP2
- ELN
- FBN1
- LOX
- LTBP2
- MEOX2
- OTX1
- TRIP13
Pathways
- Elastic Fiber Assembly
- Angiogenesis
- Pathogenesis
- Cell Proliferation
- Cell Adhesion
- Aging
- Cell Migration
- Secretion
- Glycosylation
- Cell Growth
- Cell Motility
- Parturition
- Localization
PTMs
- Cleavage
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FBLN5
bosterbio.com/bosterbio-gene-info-cards/FBLN5
References
PMID: 10428823 by Nakamura T., et al. DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries.
PMID: 15790312 by Freeman L.J., et al. Fibulin-5 interacts with fibrillin-1 molecules and microfibrils.