F-box/LRR-repeat protein 15 (Fbxl15)

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance.

Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). .