Fbxl21 Antibodies

AND Fbxl21 ELISA kits, Fbxl21 Proteins

Many biological assays use antibodies to detect Fbxl21, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Fbxl21 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Fbxl21 antibodies...

We validate the specificity of these antibodies to Fbxl21 by testing them on tissues known to express Fbxl21 positively and negatively. Browse below to find the Fbxl21 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Fbxl21 Infographic by Boster Bio

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FBXL21P (NM_012159) Human Over-expression Lysate

Human

$960
Cat # LS026223
20 µg, 100 µg

Fbxl21 Overview

Facts about F-box/LRR-repeat protein 21.

Fbxl21 3D structure. Source: alphafold

F-box/LRR-repeat protein 21 (Fbxl21)

Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a vital role in the maintenance of both the speed and the robustness of the circadian clock oscillation.

The SCF(FBXL21) complex chiefly functions in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the action of the SCF(FBXL3) complicated and shields CRY proteins from degradation.

Gene Information

Mouse
Gene Name:	Fbxl21
Uniprot:	Q8BFZ4
Entrez:	213311

Family

Belongs to:

No superfamily

Alternative Names

Fbl21; FBL3; FBL3B; F-box and leucine-rich repeat protein 21 (gene/pseudogene); F-box and leucine-rich repeat protein 21; F-box and leucine-rich repeat protein 3 pseudogene; F-box and leucine-rich repeat protein 3B; F-box protein Fbl3b; F-box/LRR-repeat protein 21; F-box/LRR-repeat protein 3B; FBXL3B; FBXL3P; MGC120237

Molecular Weight

Mass (kDA):
49.154 kDA

Genomic Context


Mouse

Location:	13\|13 B1
Sequence:	13;

Tissue Specificity

Expressed in the hypothalamus, especially in the suprachiasmatic nucleus (SCN). Expression is driven by the core-clock. There is a pronounced diurnal and circadian expression rhythms rising rapidly at the start of the day and declining at the onset of the night.

Diseases

Schizophrenia

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Fbxl21

References

PMID: 18953409 by Dardente H., et al. Implication of the F-Box Protein FBXL21 in circadian pacemaker function in mammals.

PMID: 23452855 by Yoo S.H., et al. Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.