FBXO45 Antibodies

AND FBXO45 ELISA kits, FBXO45 Proteins

Many biological assays use antibodies to detect FBXO45, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FBXO45 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FBXO45 antibodies...

We validate the specificity of these antibodies to FBXO45 by testing them on tissues known to express FBXO45 positively and negatively. Browse below to find the FBXO45 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FBXO45 Infographic by Boster Bio

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FBXO45 Overview

Facts about F-box/SPRY domain-containing protein 1.

FBXO45 3D structure. Source: alphafold

F-box/SPRY domain-containing protein 1 (FBXO45)

Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity).

Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A through ubiquitin dependent pathway (By similarity).

Gene Information

Human
Gene Name:	FBXO45
Uniprot:	P0C2W1
Entrez:	200933

Family

Belongs to:

FBXO45/Fsn family

Alternative Names

F-box only protein 45; F-box protein 45; F-box/SPRY domain-containing protein 1; Fbx45

Molecular Weight

Mass (kDA):
30.633 kDA

Genomic Context


Human

Location:	3q29
Sequence:	3; NC_000003.12 (196568660..196589059)

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane.

Diseases

Nervousness
Sclerosis
Neuroblastoma
Cell Transformation, Neoplastic
Neoplasms
Mammary Neoplasms
Tuberous Sclerosis

Respiratory Distress

Pathways

Cell Cycle
Cell Death
Innervation

PTMs

Ubiquitination

Phosphorylation

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FBXO45

References

PMID: 15520277 by Jin J., et al. Systematic analysis and nomenclature of mammalian F-box proteins.

PMID: 19581926 by Peschiaroli A., et al. The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73.