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- Table of Contents
Facts about Fc receptor-like protein 6.
Doesn't function as an Fc receptor (PubMed:18991291). .
Human | |
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Gene Name: | FCRL6 |
Uniprot: | Q6DN72 |
Entrez: | 343413 |
Belongs to: |
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No superfamily |
Fc receptor-like 6; FcRH6; FCRL6; FLJ16056; IFGP6
Mass (kDA):
47.748 kDA
Human | |
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Location: | 1q23.2 |
Sequence: | 1; NC_000001.11 (159800506..159816257) |
Expressed by cytolytic cells including NK cells, effector and effector-memory CD8(+) T-cells, and a subset of NKT cells (at protein level) (PubMed:17213291, PubMed:18991291, PubMed:20933011). Also expressed in gamma delta T cells and in a rare subset of effector CD4(+) T-cells (at protein level) (PubMed:18991291). Expressed in spleen, skin, peripheral blood leukocytes, liver, lung, bone marrow, small intestine and placenta (PubMed:20933011). Expression among T-cells is greatly expanded in HIV-1 infected individuals, and includes not only effector and effector-memory CD8(+) T-cells but also populations of CD4(+) T- cells (PubMed:17213291, PubMed:20933011). Expression among CD8(+) T-cells and NK cells is expanded in individuals with chronic lymphocytic leukemia (CLL) but is reduced in PBMCs from patients with acute (AML), chronic myeloid leukemia (CML) and non-Hodgkin's lymphoma (PubMed:18991291, PubMed:20933011). Expression is higher in PBMCs and/or CD3(+) cells of patients with autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and idiopathic thrombocytopenia purpura (ITP) (PubMed:20933011). In contrast, expression in CD3(+) cells from patien
Cell membrane; Single-pass type I membrane protein.
PMID: 17213291 by Wilson T.J., et al. FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection.
PMID: 18991291 by Schreeder D.M., et al. FCRL6 distinguishes mature cytotoxic lymphocytes and is upregulated in patients with B-cell chronic lymphocytic leukemia.