Fermitin family homolog 3 Antibodies

AND FERMT3 ELISA kits, Fermitin family homolog 3 Proteins

Many biological assays use antibodies to detect Fermitin family homolog 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Fermitin family homolog 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Fermitin family homolog 3 antibodies...

We validate the specificity of these antibodies to Fermitin family homolog 3 by testing them on tissues known to express FERMT3 positively and negatively. Browse below to find the FERMT3 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FERMT3 Infographic by Boster Bio

All FERMT3 Products

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Anti-KINDLIN3 FERMT3 Antibody

Western blot analysis of KINDLIN3 in rat spleen lysate with KINDLIN3 antibody at (A) 1 and (B) 2 μg/mL

Human, Mouse, Rat

ELISA, WB

$481
Cat # A05406
0.1 mg

Anti-URP2 (FERMT3) Mouse Monoclonal Antibody [Clone ID: OTI3C7]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FERMT3 (Right lane) cDNA for 48 hrs and lysed

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-FERMT3 mouse monoclonal antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-FERMT3 mouse monoclonal antibody

Human, Mouse, Rat

IHC, WB

$523
Cat # M05406
100 µl

URP2 (FERMT3) (NM_031471) Human Over-expression Lysate

Human

$628
Cat # LS083706
20 µg, 100 µg

Anti-Kindlin 3/FERMT3 Antibody

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$370
Cat # A05406-1
100 μl/vial

FERMT3 Overview

Facts about Fermitin family homolog 3.

FERMT3 3D structure. Source: alphafold

Fermitin family homolog 3 (FERMT3)

Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by triggering the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity).

Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).

Gene Information

Human
Gene Name:	FERMT3
Uniprot:	Q86UX7
Entrez:	83706

Family

Belongs to:

kindlin family

Alternative Names

fermitin family member 3; FERMT3; KIND3; KIND3fermitin family homolog 3 (Drosophila); Kindlin 3; Kindlin-3; MGC10966; MIG-2; MIG2B; MIG2BURP2SF; MIG2-like protein; UNC-112 related protein 2; UNC112C; Unc-112-related protein 2; URP2; URP2fermitin family homolog 3; URP2SF

Molecular Weight

Mass (kDA):
75.953 kDA

Genomic Context


Human

Location:	11q13.1
Sequence:	11; NC_000011.10 (64206662..64223891)

Tissue Specificity

Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.

Subcellular Localizations

Cell projection, podosome. Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.

Diseases

Tissue Adhesions
Leukocyte-adhesion Deficiency Syndrome
Hemorrhage
Infective Disorder
Leukocyte Adhesion Deficiency
Neoplasms
Bleeding Tendency
De Novo Mutation
Carcinoma
Immunologic Deficiency Syndromes
Malignant Neoplasms
Bacterial Infections
Genetic Diseases, Inborn

Neoplasm Metastasis
Hemorrhagic Disorders
Malignant Tumor Of Colon
Persistant Generalized Lymphadenopathy
Carcinogenesis
Thrombasthenia
Impaired Healing

Pathways

Integrin Activation
Reverse Transcription
Regulation Of Integrin Activation
Immune Response
Cell Growth
Wound Healing
Fucosylation

Secretion

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FERMT3

References

PMID: 12697302 by Weinstein E.J., et al. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas.

PMID: 12886250 by Boyd R.S., et al. Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B.