FGD4 Antibodies

AND FGD4 ELISA kits, FGD4 Proteins

Many biological assays use antibodies to detect FGD4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FGD4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FGD4 antibodies...

We validate the specificity of these antibodies to FGD4 by testing them on tissues known to express FGD4 positively and negatively. Browse below to find the FGD4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FGD4 Infographic by Boster Bio

All FGD4 Products

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Product

Figures

Specificity

Applications

Price

Anti-FGD4 Antibody

Western blot analysis of extracts of various cell lines, using FGD4 antibody at 1:1000 dilution

Human, Mouse, Rat

$405
Cat # A10604
100ul

FGD4 (NM_139241) Human Recombinant Protein

Coomassie blue staining of purified FGD4 protein

$1062
Cat # PROTQ96M96
20 µg

FGD4 (NM_139241) Human Over-expression Lysate

Human

$960
Cat # LS121512
20 µg, 100 µg

FGD4 Overview

Facts about FYVE, RhoGEF and PH domain-containing protein 4.

FGD4 3D structure. Source: alphafold

FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)

Activates CDC42, a Part of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP.
Plays a role in regulating the actin cytoskeleton and cell shape.

Activates MAPK8 (By similarity). .

Gene Information

Human
Gene Name:	FGD4
Uniprot:	Q96M96
Entrez:	121512

Family

Belongs to:

No superfamily

Alternative Names

Actin filament-binding protein frabin; CMT4HFLJ42663; DKFZp313E1818; FGD1 family, member 4; frabin; FRABPDKFZp434K1572; FYVE, RhoGEF and PH domain containing 4; MGC57222; RhoGEF and PH domain-containing protein 4; ZFYVE6FLJ34370

Molecular Weight

Mass (kDA):
86.626 kDA

Genomic Context


Human

Location:	12p11.21
Sequence:	12; NC_000012.12 (32399523..32646050)

Tissue Specificity

Expressed in different tissues, including brain, cerebellum, peripheral nerve, skeletal muscle, heart, uterus, placenta and testis.

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell projection, filopodium. Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity).

Diseases

Charcot-marie-tooth Disease
Hereditary Motor And Sensory Neuropathies
Malignant Neoplasms
Peripheral Neuropathy
Sensory Neuropathy
Carcinoma
Nervousness
Congenital Abnormality
Demyelination
Weakness
Malignant Neoplasm Of Breast
Head And Neck Carcinoma

Hand Deformities
Immediate Hypersensitivity
Dysplasia
Patient Dependence On
Head And Neck Neoplasms
Malignant Neck Neoplasm

Pathways

Myelination
Mitochondrial Fusion
Actin Cytoskeleton Reorganization
Cell Migration
Dna Methylation
Cellular Process
Endocytosis
Nerve Development
Methylation
Myelin Maintenance

Cell Motility
Cell Differentiation
Pathogenesis
Rna Interference

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FGD4

References

PMID: 15133042 by Chen X.M., et al. Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42.

PMID: 17564959 by Delague V., et al. Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H.