FGD5 Antibodies

AND FGD5 ELISA kits, FGD5 Proteins

Many biological assays use antibodies to detect FGD5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FGD5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FGD5 antibodies...

We validate the specificity of these antibodies to FGD5 by testing them on tissues known to express FGD5 positively and negatively. Browse below to find the FGD5 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FGD5 Infographic by Boster Bio

All FGD5 Products

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Anti-FGD5 Antibody Picoband®

Western blot analysis of FGD5 using anti-FGD5 antibody (A09444-1)

Flow Cytometry analysis of 293T cells using anti-FGD5 antibody (A09444-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A09444-1
100 μg/vial

FGD5 Overview

Facts about FYVE, RhoGEF and PH domain-containing protein 5.

FGD5 3D structure. Source: alphafold

FYVE, RhoGEF and PH domain-containing protein 5 (FGD5)

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP.
Mediates VEGF-induced CDC42 activation.

May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.

Gene Information

Human
Gene Name:	FGD5
Uniprot:	Q6ZNL6
Entrez:	152273

Family

Belongs to:

No superfamily

Alternative Names

FLJ00274; FLJ39957; FYVE, RhoGEF and PH domain containing 5; FYVE, RhoGEF and PH domain-containing protein 5; ZFYVE23Zinc finger FYVE domain-containing protein 23

Molecular Weight

Mass (kDA):
159.891 kDA

Genomic Context


Human

Location:	3p25.1
Sequence:	3; NC_000003.12 (14818962..14934571)

Tissue Specificity

Expressed in endothelial cells (at protein level).

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.

Diseases

Tumor Angiogenesis
Pathologic Neovascularization
Adenocarcinoma
Neoplasm Metastasis
Malignant Squamous Cell Neoplasm
Ischemia
Non-small Cell Lung Carcinoma
Tumor Progression
Von Hippel-lindau Syndrome
Tissue Adhesions
Protrusion
Malignant Neoplasm Of Lung

Carcinogenesis
Carcinoma
Cataract
Malignant Neoplasms
Neoplasms
Inflammation
Retinal Diseases

Interacting Proteins

SUV39H1

Pathways

Angiogenesis
Methylation
Transport
Vesicle Transport
Organ Development
Aging
Cell Growth
Localization

Rna Interference
Autophagy

PTMs

Phosphorylation

Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FGD5

References

PMID: 10737800 by Dias Neto E., et al. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

PMID: 22328776 by Kurogane Y., et al. FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells.