FHOD3 Antibodies

AND FHOD3 ELISA kits, FHOD3 Proteins

Many biological assays use antibodies to detect FHOD3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FHOD3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FHOD3 antibodies...

We validate the specificity of these antibodies to FHOD3 by testing them on tissues known to express FHOD3 positively and negatively. Browse below to find the FHOD3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FHOD3 Infographic by Boster Bio

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FHOD3 (NM_025135) Human Over-expression Lysate

Human

$960
Cat # LS080206
20 µg, 100 µg

FHOD3 Overview

Facts about FH1/FH2 domain-containing protein 3.

FHOD3 3D structure. Source: alphafold

FH1/FH2 domain-containing protein 3 (FHOD3)

Actin-organizing protein that might cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes.

Gene Information

Human
Gene Name:	FHOD3
Uniprot:	Q2V2M9
Entrez:	80206

Family

Belongs to:

formin homology family

Alternative Names

FH1/FH2 domain-containing protein 3; FHOS2; Formactin2; formactin-2; formin homolog overexpressed in spleen 2; formin homology 2 domain containing 3; hFHOS2; KIAA1695

Molecular Weight

Mass (kDA):
158.613 kDA

Genomic Context


Human

Location:	18q12.2
Sequence:	18; NC_000018.10 (36297713..36780220)

Tissue Specificity

Expressed in the heart, kidney and brain. May be down-regulated in various types of heart diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated cardiomyopathies, as well as ischemic heart disease (at protein level).

Subcellular Localizations

Cytoplasm, cytoskeleton. Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining.; [Isoform 4]: Cytoplasm, myofibril, sarcomere, Z line. Threonine phosphorylation in isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes.

Diseases

Chondrosarcoma
Dislocations
Neoplasms
Cell Invasion
Bladder Neoplasm
Glioblastoma
Parathyroid Neoplasms
Schizophrenia
Tissue Adhesions
Acute Lymphocytic Leukemia
Autoimmune Diseases
Diabetes Mellitus
Carcinogenesis

Carcinoid Tumor
Metabolic Diseases
Retinoblastoma
Cardiomyopathies
Malignant Neoplasms
Autoimmune Reaction
Leukemia

Interacting Proteins

SQSTM1

Pathways

Sarcomere Organization
Heart Development
Localization
Spermatogenesis
Transport
Cell Division
Limb Morphogenesis
Ion Transport

Glycosylation
Tissue Homeostasis

PTMs

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FHOD3

References

PMID: 15966898 by Kanaya H., et al. Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament.

PMID: 21149568 by Iskratsch T., et al. Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance.