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- Table of Contents
FKBP5 Antibodies
AND FKBP5 ELISA kits, FKBP5 Proteins
Many biological assays use antibodies to detect FKBP5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FKBP5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FKBP5 antibodies...
Designing a Western blot for FKBP5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FKBP5 Western Blot GuideDesigning an IHC experiment for FKBP5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the FKBP5 IHC GuideFKBP5 Infographic by Boster Bio
All FKBP5 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M04182
100 μl
Cat # M04182
100 μl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M02165-2
100 μl/vial
Cat # M02165-2
100 μl/vial
FKBP5 Overview
Facts about Peptidyl-prolyl cis-trans isomerase FKBP5.
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)
Immunophilin protein with PPIase and co-chaperone actions. Part of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90).
Plays a role in the intracellular trafficking of heterooligomeric kinds of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. .
Gene Information
| Human | |
|---|---|
| Gene Name: | FKBP5 |
| Uniprot: | Q13451 |
| Entrez: | 2289 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
51 kDa FKBP; 54 kDa progesterone receptor-associated immunophilin; AIG6,51 kDa FK506-binding protein; Androgen-regulated protein 6; Dit1; FF1 antigen; FK506 binding protein 5; FK506-binding protein 5; FKBP5; FKBP-5; FKBP51; FKBP-51; FKBP51PPIase FKBP5; FKBP54; FKBP54EC 5.2.1.8; HSP90-binding immunophilin; MGC111006; p54; P54,51 kDa FK506-binding protein 5; peptidyl-prolyl cis-trans isomerase FKBP5; peptidylprolyl cis-trans isomerase; PPIase; Ptg-10; rotamase; T-cell FK506-binding protein
Molecular Weight
Mass (kDA):
51.212 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.31 |
| Sequence: | 6; NC_000006.12 (35573585..35728583, complement) |
Tissue Specificity
Widely expressed, enriched in testis compared to other tissues.
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Depressive Disorder
- Malignant Neoplasms
- Post-traumatic Stress Disorder
- Major Depressive Disorder
- Neoplasms
- Anxiety Disorders
- Mood Disorders
- Malignant Neoplasm Of Prostate
- Stress, Psychological
- Bipolar Disorder
- Cancer Patients And Suicide And Depression
- Prostatic Neoplasms
Interacting Proteins
- CDK15
- CDK9
- CHUK
- HSP90AB1
- KSR2
- MOS
- STK11
- USP49
Pathways
- Response To Antidepressant
- Methylation
- Dna Methylation
- Pathogenesis
- Transport
- Immune Response
- Sensitization
- Cell Cycle
- Cortisol Secretion
- Cell Death
- Cell Growth
- Secretion
- Cell Adhesion
PTMs
- Phosphorylation
- Methylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FKBP5
bosterbio.com/bosterbio-gene-info-cards/FKBP5
References
PMID: 9125197 by Baughman G., et al. Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition.
PMID: 9001212 by Nair S.C., et al. Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor.