FNIP1 Antibodies

AND FNIP1 ELISA kits, FNIP1 Proteins

Many biological assays use antibodies to detect FNIP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FNIP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FNIP1 antibodies...

We validate the specificity of these antibodies to FNIP1 by testing them on tissues known to express FNIP1 positively and negatively. Browse below to find the FNIP1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FNIP1 Infographic by Boster Bio

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FNIP1 (NM_133372) Human Over-expression Lysate

Human

$960
Cat # LS096459
20 µg, 100 µg

FNIP1 Overview

Facts about Folliculin-interacting protein 1.

FNIP1 3D structure. Source: alphafold

Folliculin-interacting protein 1 (FNIP1)

Acts as a co-chaperone of HSP90AA1.
Inhibits the ATPase activity of HSP90AA1 leading to decrease in its chaperone activity.

Facilitates the binding of customer protein FLCN to HSP90AA1. Competes with the tripping co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360).

Gene Information

Human
Gene Name:	FNIP1
Uniprot:	Q8TF40
Entrez:	96459

Family

Belongs to:

FNIP family

Alternative Names

DKFZp781P0215; folliculin interacting protein 1; folliculin-interacting protein 1; KIAA1961DKFZp686E18167; MGC667

Molecular Weight

Mass (kDA):
130.555 kDA

Genomic Context


Human

Location:	5q31.1
Sequence:	5; NC_000005.10 (131641714..131797017, complement)

Tissue Specificity

Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.

Subcellular Localizations

Cytoplasm. Colocalizes with FLCN in the cytoplasm.

Diseases

Neoplasms
Kidney Neoplasm
Multiple Fibrofolliculomas
Renal Cell Carcinoma
Benign Neoplasm
Sclerosis
Leukemogenesis
Hamartoma
Primary Lateral Sclerosis
Malignant Neoplasm Of Kidney
Oncogene Activation Process

Dementia
Amyotrophic Lateral Sclerosis
Carcinoma
Conventional (clear Cell) Renal Cell Carcinoma
Malignant Neoplasms
Oncocytic Neoplasm

Interacting Proteins

FLCN
GABARAP
GABARAPL1

Pathways

Cell Death
Cell Development
Cell Growth
Pathogenesis
Chromosome Segregation
Autophagy

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FNIP1

References

PMID: 17028174 by Baba M., et al. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.

PMID: 18403135 by Hasumi H., et al. Identification and characterization of a novel folliculin-interacting protein FNIP2.