Folate receptor beta Antibodies

AND FOLR2 ELISA kits, Folate receptor beta Proteins

Many biological assays use antibodies to detect Folate receptor beta, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Folate receptor beta in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Folate receptor beta antibodies...

We validate the specificity of these antibodies to Folate receptor beta by testing them on tissues known to express FOLR2 positively and negatively. Browse below to find the FOLR2 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CCN2 Next: FOLR3

FOLR2 Infographic by Boster Bio

All FOLR2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human FOLR2/Beta Fr ELISA Kit PicoKine®

8 Q&As

Human

ELISA

$499
Cat # EK1539
96 wells/kit, with removable strips.

Anti-FOLR2 Purified Monoclonal Antibody

Western blotting analysis of FOLR2 in THP1 cells (A) and FOLR2-transfected THP1 cells (B) using anti-FOLR2 (EM-35) purified

Separation of FORL2 transfected BW5147 cells stained using anti-FOLR2 (EM-35) purified antibody (concentration in sample 4 µg/ml, GAM APC, red-filled) from FORL2 transfekted BW5147 cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining)

Human

Flow Cytometry, IP, ICC, WB

$304
Cat # M04574
0.1 mg

Anti-Folate receptor beta FOLR2 Antibody

Western blot analysis of lysates from SH-SY5Y cells, primary antibody was diluted at 1:1000, 4°over night

Human, Mouse

ELISA, WB

$380
Cat # A04574
100ul

Anti-FOLR2 Antibody

Human

$299
Cat # M04574-1
50 µl

Anti-FOLR2 Mouse Monoclonal Antibody [Clone ID: OTI4G6]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FOLR2 (Right lane) cDNA for 48 hrs and lysed

Human

IHC, WB

$523
Cat # M04574-2
100 µl

FOLR2 (NM_000803) Human Over-expression Lysate

Human

$628
Cat # LS002350
20 µg, 100 µg

FOLR2 Overview

Facts about Folate receptor beta.

FOLR2 3D structure. Source: alphafold

Folate receptor beta (FOLR2)

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs to the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.

Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that dramatically reduces its affinity for folates and mediates their release. .

Gene Information

Human
Gene Name:	FOLR2
Uniprot:	P14207
Entrez:	2350

Family

Belongs to:

folate receptor family

Alternative Names

beta-HFR; FBP; FBP/PL-1; folate receptor 2 (fetal); Folate receptor 2; folate receptor beta; folate receptor, beta; Folate receptor, fetal/placental; folate-binding protein, fetal/placental; FOLR2; FR-beta; FR-P3; Placental folate-binding protein

Molecular Weight

Mass (kDA):
29.28 kDA

Genomic Context


Human

Location:	11q13.4
Sequence:	11; NC_000011.10 (72216794..72221950)

Tissue Specificity

Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor. Secreted.

Diseases

5,10-methylenetetrahydrofolate Reductase Deficiency
Congenital Abnormality
Neoplasms
Dysequilibrium Syndrome
Melanoma
Exencephaly
Hypoxia
Teratogenic Effect
Fetal Growth Retardation
Congenital Cerebral Hernia
Ulcer
Congenital Heart Defects
Malignant Neoplasms

Nervousness
Malignant Neoplasm Of Ovary
Ovarian Neoplasm
Cleft Lip
Colitis
Myeloproliferative Syndrome, Transient
Meningomyelocele

Pathways

Transport
Methylation
Tube Closure
Regulation Of I-kappab Kinase/nf-kappab Cascade
Neural Tube Closure
Response To Hypoxia
Tube Formation
I-kappab Kinase/nf-kappab Cascade
Oxidative Phosphorylation

Neural Tube Formation
Macrophage Activation
Embryo Development

PTMs

Phosphorylation

Deacetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOLR2

References

PMID: 8445646 by Page S.T., et al. Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene.

PMID: 2605182 by Ratnam M., et al. Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA.