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Forkhead box protein C1 Antibodies
AND FOXC1 ELISA kits, Forkhead box protein C1 Proteins
Many biological assays use antibodies to detect Forkhead box protein C1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Forkhead box protein C1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Forkhead box protein C1 antibodies...
Designing a Western blot for Forkhead box protein C1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FOXC1 Western Blot GuideFOXC1 Infographic by Boster Bio
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FOXC1 Overview
Facts about Forkhead box protein C1.
Forkhead box protein C1 (FOXC1)
DNA-binding transcriptional factor that plays a part in a broad selection of developmental and cellular processes like eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:15299087, PubMed:15684392, PubMed:16492674, PubMed:27907090, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:16449236, PubMed:17210863, PubMed:19793056, PubMed:19279310, PubMed:25786029, PubMed:27804176). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:7957066, PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176).
Upon DNA-binding, promotes DNA bending (PubMed:7957066, PubMed:14506133). Stimulates Indian hedgehog (Ihh)- induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | FOXC1 |
| Uniprot: | Q12948 |
| Entrez: | 2296 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ARA; FKHL7; FKHL7RIEG3; forkhead box C1; forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead/winged helix-like transcription factor 7; forkhead-related activator 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FoxC1; FREAC3; FREAC-3; FREAC3IRID1; IGDA; IHG1; IRID1; myeloid factor-delta; RIEG3
Molecular Weight
Mass (kDA):
56.789 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p25.3 |
| Sequence: | 6; NC_000006.12 (1609915..1613897) |
Tissue Specificity
Expressed in keratinocytes of epidermis and hair follicle (PubMed:27907090). Expressed strongly in microvascular invasion (MVI) formation, basal-like breast cancer (BLBC) and hepatocellular tumors (PubMed:20406990, PubMed:22991501). Expressed in breast cancers (at protein level) (PubMed:26565916). Expressed in hematopoietic cells (PubMed:8499623).
Subcellular Localizations
Nucleus. Colocalizes with PITX2 isoform 3 in the nucleus at subnuclear chromatine regions (PubMed:16449236). Colocalizes with CBX5 to a heterochromatin-rich region of the nucleus (PubMed:15684392). Colocalizes with GLI2 in the nucleus (By similarity).
Diseases
- Glaucoma
- Eye Abnormalities
- Congenital Abnormality
- Rieger Syndrome
- Irido-corneal Dysgenesis
- Malignant Neoplasms
- Corneal Diseases
- Hypoplasia
- Intraocular Pressure Disorder
- Neoplasms
- Malignant Neoplasm Of Breast
- Hydrophthalmos
- Mammary Neoplasms
Interacting Proteins
- C1QBP
- FLNA
- PBX1
Pathways
- Pathogenesis
- Eye Development
- Localization
- Cell Proliferation
- Methylation
- Dna Methylation
- Somitogenesis
- Bone Development
- Angiogenesis
- Cell Differentiation
- Notch Signaling Pathway
- Cell Migration
- Ossification
PTMs
- Phosphorylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOXC1
bosterbio.com/bosterbio-gene-info-cards/FOXC1
References
PMID: 9620769 by Nishimura D.Y., et al. The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25.
PMID: 9792859 by Mears A.J., et al. Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly.