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- Table of Contents
Forkhead box protein O3 Antibodies
AND FOXO3 ELISA kits, Forkhead box protein O3 Proteins
Many biological assays use antibodies to detect Forkhead box protein O3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Forkhead box protein O3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Forkhead box protein O3 antibodies...
Designing a Western blot for Forkhead box protein O3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FOXO3 Western Blot GuideFOXO3 Infographic by Boster Bio
All FOXO3 Products
Product
Figures
Specificity
Applications
Price
Anti-FOXO3A Antibody Picoband®
4 Citations
Human, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9196
100 μg/vial
Cat # PB9196
100 μg/vial
Anti-FoxO3a Rabbit Monoclonal Antibody
4 Citations
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # M00252
100 μl
Cat # M00252
100 μl
Human, Mouse, Rat
IHC, WB
$370
Cat # P00252
100 μl
Cat # P00252
100 μl
Human, Mouse, Rat
IP, WB
$370
Cat # P00261
100 μl/vial
Cat # P00261
100 μl/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00252-2
20μL, 40μL, 100μL, 200μL
Cat # M00252-2
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA, IF, ICC, WB
$481
Cat # A00252
0.1 mg
Cat # A00252
0.1 mg
Human, Mouse, Rat
ELISA
$540
Cat # EKC2412
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2412
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1217
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1217
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A00252-3
100 μg/vial
Cat # A00252-3
100 μg/vial
FOXO3 Overview
Facts about Forkhead box protein O3.
Forkhead box protein O3 (FOXO3)
Transcriptional activator which activates apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882).
Participates in post-transcriptional regulation of MYC: after phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, two post-transcriptional labs of MYC that bind to the 3'UTR of MYC transcript and prevent its interpretation (PubMed:21329882). In response to metabolic stress, translocates to the mitochondria where it promotes mtDNA transcription (PubMed:23283301).
Gene Information
| Human | |
|---|---|
| Gene Name: | FOXO3 |
| Uniprot: | O43524 |
| Entrez: | 2309 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AF6q21 protein; AF6q21; DKFZp781A0677; FKHRL1; FKHRL1MGC31925; FKHRL1P2; forkhead box O3; forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma-like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO2; FoxO3; FOXO3A; FOXO3Aforkhead box O3A; MGC12739
Molecular Weight
Mass (kDA):
71.277 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q21 |
| Sequence: | 6; NC_000006.12 (108559825..108684774) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cytoplasm, cytosol. Nucleus. Mitochondrion matrix. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106). Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106). Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity). Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Atrophy
- Muscular Atrophy
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Leukemia
- Diabetes Mellitus
- Inflammation
- Hypertrophy
Interacting Proteins
- AKT1
- ARHGEF2
- CDC27
- CREBBP
- ESR1
- ESR2
- Foxg1
- FOXK1
- FOXM1
- HCFC1
Pathways
- Cell Cycle
- Cell Death
- Localization
- Cell Proliferation
- Aging
- Cell Growth
- Cell Cycle Arrest
- Autophagy
- Muscle Atrophy
- Pathogenesis
- Nuclear Export
- Proteolysis
- Cell Differentiation
PTMs
- Phosphorylation
- Dephosphorylation
- Acetylation
- Deacetylation
- Cleavage
- Methylation
Research Areas
- Apoptosis
- Cancer
- DNA Repair
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOXO3
bosterbio.com/bosterbio-gene-info-cards/FOXO3
References
PMID: 9479491 by Anderson M.J., et al. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.
PMID: 9345057 by Hillion J., et al. AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily.
1 Publications of Boster Forkhead box protein O3 Antibodies & ELISA Kits
- PubMed ID: 10.3390/ijms22042225, Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic ...
*More publications can be found for each product on its corresponding product page