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Participates in post-transcriptional regulation of MYC: after phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, two post-transcriptional labs of MYC that bind to the 3'UTR of MYC transcript and prevent its interpretation (PubMed:21329882). In response to metabolic stress, translocates to the mitochondria where it promotes mtDNA transcription (PubMed:23283301).
|Sequence:||6; NC_000006.12 (108559825..108684774)|
Cytoplasm, cytosol. Nucleus. Mitochondrion matrix. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106). Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106). Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity). Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed: