Forkhead box protein O3 (FOXO3)

Transcriptional activator which activates apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882).

Participates in post-transcriptional regulation of MYC: after phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, two post-transcriptional labs of MYC that bind to the 3'UTR of MYC transcript and prevent its interpretation (PubMed:21329882). In response to metabolic stress, translocates to the mitochondria where it promotes mtDNA transcription (PubMed:23283301).