FRMD4A Antibodies

AND FRMD4A ELISA kits, FRMD4A Proteins

Many biological assays use antibodies to detect FRMD4A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FRMD4A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FRMD4A antibodies...

We validate the specificity of these antibodies to FRMD4A by testing them on tissues known to express FRMD4A positively and negatively. Browse below to find the FRMD4A antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FRMD4A Infographic by Boster Bio

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FRMD4A Overview

Facts about FERM domain-containing protein 4A.

FRMD4A 3D structure. Source: alphafold

FERM domain-containing protein 4A (FRMD4A)

Scaffolding protein which modulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity).

May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). .

Gene Information

Human
Gene Name:	FRMD4A
Uniprot:	Q9P2Q2
Entrez:	55691

Family

Belongs to:

No superfamily

Alternative Names

FERM domain-containing protein 4A

Molecular Weight

Mass (kDA):
115.458 kDA

Genomic Context


Human

Location:	10p13
Sequence:	10; NC_000010.11 (13638300..14330924, complement)

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, tight junction. Colocalized with CYTH1 at adherens junction and tight junction. Colocalized with PARD3 during the process of epithelial polarization.

Diseases

Agenesis of the corpus callosum, with facial anomalies and cerebellar ataxia (CCAFCA)

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FRMD4A

References

PMID: 25388005 by Fine D., et al. A syndrome of congenital microcephaly, intellectual disability and dysmorphism with a homozygous mutation in FRMD4A.

PMID: 27044754 by Yan X., et al. FRMD4A-cytohesin signaling modulates the cellular release of tau.