FRS3 Antibodies

AND FRS3 ELISA kits, FRS3 Proteins

Many biological assays use antibodies to detect FRS3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FRS3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FRS3 antibodies...

We validate the specificity of these antibodies to FRS3 by testing them on tissues known to express FRS3 positively and negatively. Browse below to find the FRS3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FRS3 Infographic by Boster Bio

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SNT2 (FRS3) (NM_006653) Human Over-expression Lysate

Human

$628
Cat # LS010817
20 µg, 100 µg

FRS3 Overview

Facts about Fibroblast growth factor receptor substrate 3.

FRS3 3D structure. Source: alphafold

Fibroblast growth factor receptor substrate 3 (FRS3)

Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases.

Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2. .

Gene Information

Human
Gene Name:	FRS3
Uniprot:	O43559
Entrez:	10817

Family

Belongs to:

No superfamily

Alternative Names

FGFR substrate 3; FGFR-signaling adaptor SNT2; fibroblast growth factor receptor substrate 3; FRS2B; FRS2beta; FRS2-beta; SNT2; SNT-2MGC17167; suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor); Suc1-associated neurotrophic factor target 2

Molecular Weight

Mass (kDA):
54.462 kDA

Genomic Context


Human

Location:	6p21.1
Sequence:	6; NC_000006.12 (41770176..41779900, complement)

Subcellular Localizations

Membrane; Lipid-anchor.

Diseases

Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Metaplastic Cell Transformation
Cell Invasion
Malignant Neoplasm Of Prostate
Lung Neoplasms
Non-small Cell Lung Carcinoma
Malignant Neoplasm Of Breast
Ki-1+ Anaplastic Large Cell Lymphoma
Malignant Paraganglionic Neoplasm
Invasive Breast Carcinoma
Malignant Neoplasm Of Lung

Carcinogenesis
Thyroid Neoplasm
Prostatic Neoplasms
Diffuse Large B-cell Lymphoma
Nervousness
T(2;5)(p23;q35)
Chromosomal Translocation

Interacting Proteins

AES
GATA1
NOTCH2NL
PIK3R3
PLSCR1

RFX6
SOCS4
SPERT
SPRY2
TCF4

TRIP6

Pathways

Cell Proliferation
Tube Closure
Cell Division
Neural Tube Closure
Gastrulation
Parturition
Cell Cycle
Signal Transmission
Somitogenesis

Neurogenesis
Cell Growth
Localization

PTMs

Phosphorylation

Acetylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FRS3

References

PMID: 9660748 by Xu H., et al. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins.

PMID: 15485655 by Huang L., et al. SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.