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- Table of Contents
Facts about Furin.
Human | |
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Gene Name: | FURIN |
Uniprot: | P09958 |
Entrez: | 5045 |
Belongs to: |
---|
peptidase S8 family |
Dibasic-processing enzyme; EC 3.4.21; EC 3.4.21.75; FUR; FURdibasic processing enzyme; furin (paired basic amino acid cleaving enzyme); Furin; furin, membrane associated receptor protein; PACE; PACEFES upstream region; paired basic amino acid cleaving enzyme (furin, membrane associated receptorprotein); Paired basic amino acid residue-cleaving enzyme; PC; PCSK3; PCSK3furin; proprotein convertase subtilisin/kexin type 3; SPC1
Mass (kDA):
86.678 kDA
Human | |
---|---|
Location: | 15q26.1 |
Sequence: | 15; NC_000015.10 (90868588..90883458) |
Seems to be expressed ubiquitously.
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Secreted. Endosome membrane; Single-pass type I membrane protein. Shuttles between the trans-Golgi network and the cell surface (PubMed:9412467, PubMed:11799113). Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin (PubMed:11799113).
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PMID: 2408021 by van den Ouweland A.M.W., et al. Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2.
PMID: 2251280 by Wise R.J., et al. Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.