Receptor-type tyrosine-protein kinase FLT3 (FLT3)

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and modulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR.

Promotes activation of RAS signaling and phosphorylation of downstream kinases, such as MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B.