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- Table of Contents
Facts about Receptor-type tyrosine-protein kinase FLT3.
Promotes activation of RAS signaling and phosphorylation of downstream kinases, such as MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B.
Human | |
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Gene Name: | FLT3 |
Uniprot: | P36888 |
Entrez: | 2322 |
Belongs to: |
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protein kinase superfamily |
CD135 antigen; CD135; EC 2.7.10; fetal liver kinase 2; FL cytokine receptor; FLK2; Flk-2; FLT3 receptor tyrosine kinase; Flt3; Flt-3; Fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; Stem cell tyrosine kinase 1; STK-1; STK1EC 2.7.10.1; Tyrosine-protein kinase receptor FLT3
Mass (kDA):
112.903 kDA
Human | |
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Location: | 13q12.2 |
Sequence: | 13; NC_000013.11 (28003274..28100587, complement) |
Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia.
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.
PMID: 7507245 by Small D., et al. STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.
PMID: 8394751 by Rosnet O., et al. Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells.