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Formin-binding protein 1 Antibodies
AND Fnbp1 ELISA kits, Formin-binding protein 1 Proteins
Many biological assays use antibodies to detect Formin-binding protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Formin-binding protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Formin-binding protein 1 antibodies...
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Fnbp1 Overview
Facts about Formin-binding protein 1.
Formin-binding protein 1 (Fnbp1)
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late phase of clathrin-mediated endocytosis. Binds to lipids like phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules.
Also enhances actin polymerization through the recruitment of WASL/N-WASP, which subsequently activates the Arp2/3 complex. Actin polymerization may foster the fission of membrane tubules to form endocytic vesicles.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Fnbp1 |
| Uniprot: | Q80TY0 |
| Entrez: | 14269 |
Family
| Belongs to: |
|---|
| FNBP1 family |
Alternative Names
FBP17KIAA0554Formin-binding protein 17; formin binding protein 1; formin-binding protein 1; hFBP17; MGC126804
Molecular Weight
Mass (kDA):
71.344 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 2|2 B |
| Sequence: | 2; |
Tissue Specificity
Expressed in brain and testis.
Diseases
- Neoplasms
- Malignant Neoplasms
- Leukemia
- Wiskott-aldrich Syndrome
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Chondrosarcoma
- Cell Invasion
- Retinoblastoma
- Neoplasm Metastasis
- Oncogene Activation Process
- Moderate Mental Retardation
Pathways
- Endocytosis
- Membrane Tubulation
- Localization
- Cell Division
- Membrane Invagination
- Clathrin-mediated Endocytosis
- Cell Migration
- Cell Motility
- Actin Nucleation
- Transport
- Actin Cytoskeleton Reorganization
- Gene Silencing
- Dna Methylation
PTMs
- Phosphorylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Fnbp1
bosterbio.com/bosterbio-gene-info-cards/Fnbp1
References
PMID: 15252009 by Kamioka Y., et al. A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.