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- Table of Contents
Forkhead box protein O4 Antibodies
AND FOXO4 ELISA kits, Forkhead box protein O4 Proteins
Many biological assays use antibodies to detect Forkhead box protein O4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Forkhead box protein O4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Forkhead box protein O4 antibodies...
Designing a Western blot for Forkhead box protein O4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FOXO4 Western Blot GuideFOXO4 Infographic by Boster Bio
All FOXO4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M01819-1
100 μl
Cat # M01819-1
100 μl
Human, Mouse
ELISA
$540
Cat # EKC2550
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2550
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2413
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2413
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2317
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2317
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1224
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1224
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IF, ICC, WB
$481
Cat # A01819
0.1 mg
Cat # A01819
0.1 mg
Human, Mouse
ELISA
$480
Cat # EKC1926
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1926
1 kit, containing one 96-well plate and all necessary reagents
FOXO4 Overview
Facts about Forkhead box protein O4.
Forkhead box protein O4 (FOXO4)
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1.
Down-regulates expression of HIF1A and inhibits hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.
Gene Information
| Human | |
|---|---|
| Gene Name: | FOXO4 |
| Uniprot: | P98177 |
| Entrez: | 4303 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AFX; AFX1myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog);translocated to, 7; Fork head domain transcription factor AFX1; forkhead box O4; forkhead box protein O4; MLLT7MGC120490; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);translocated to, 7
Molecular Weight
Mass (kDA):
53.684 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq13.1 |
| Sequence: | X; NC_000023.11 (71095851..71103534) |
Tissue Specificity
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.
Subcellular Localizations
Cytoplasm. Nucleus. When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Diabetes Mellitus
- Muscular Atrophy
- Atrophy
- Hyperplasia
- Rhabdomyosarcoma
- Carcinoma
- Leukemia
- Inflammation
- Ischemia
Interacting Proteins
- REL
- SFN
- SIRT1
- SMAD4
Pathways
- Cell Cycle
- Cell Proliferation
- Aging
- Cell Cycle Arrest
- Localization
- Cell Death
- Muscle Atrophy
- Response To Oxidative Stress
- Pathogenesis
- Cell Differentiation
- Cell Growth
- Angiogenesis
- Nuclear Export
PTMs
- Phosphorylation
- Acetylation
- Ubiquitination
- Deacetylation
Research Areas
- Cell Cycle and Replication
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOXO4
bosterbio.com/bosterbio-gene-info-cards/FOXO4
References
PMID: 9341872 by Peters U., et al. AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism.
PMID: 9010221 by Borkhardt A., et al. Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23).