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GALNT12 Antibodies
AND GALNT12 ELISA kits, GALNT12 Proteins
Many biological assays use antibodies to detect GALNT12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GALNT12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GALNT12 antibodies...
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GALNT12 Infographic by Boster Bio
All GALNT12 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A09946
100 μg/vial
Cat # A09946
100 μg/vial
GALNT12 Overview
Facts about Polypeptide N-acetylgalactosaminyltransferase 12.
Polypeptide N-acetylgalactosaminyltransferase 12 (GALNT12)
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has action toward non-glycosylated peptides like Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7.
Displays enzymatic activity toward the Gal-NAc- Muc5AC glycopeptide, but no detectable activity to mono-GalNAc- glycosylated Muc1a, Muc2, Muc7 and EA2. May play an essential role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.
Gene Information
| Human | |
|---|---|
| Gene Name: | GALNT12 |
| Uniprot: | Q8IXK2 |
| Entrez: | 79695 |
Family
| Belongs to: |
|---|
| glycosyltransferase 2 family |
Alternative Names
colorectal cancer, susceptibility to 1; CRCS1; EC 2.4.1.41; FLJ21212; GalNAc-T12; GALNT12; Polypeptide GalNAc transferase 12; polypeptide N-acetylgalactosaminyltransferase 12; Pp-GaNTase 12; Protein-UDP acetylgalactosaminyltransferase 12; UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12; UDP-N-acetyl-alpha-D-galactosamine:polypeptideN-acetylgalactosaminyltransferase 12 (GalNAc-T12)
Molecular Weight
Mass (kDA):
66.938 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q22.33 |
| Sequence: | 9; NC_000009.12 (98807670..98850081) |
Tissue Specificity
Widely expressed at different levels of expression. Highly expressed in digestive organs such as small intestine, stomach, pancreas and colon. Expressed at intermediate level in testis, thyroid gland and spleen. Weakly expressed in whole brain, cerebral cortex, cerebellum, fetal brain, bone marrow, thymus, leukocytes, heart, skeletal muscle, liver, lung, esophagus, kidney, adrenal gland, mammary gland, uterus, placenta, ovary and prostate.
Subcellular Localizations
Golgi apparatus membrane; Single-pass type II membrane protein.
Diseases
- Malignant Neoplasms
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Colorectal Cancer
- Neoplasms
- Colorectal Neoplasms
- Stomach Neoplasms
- Neoplasm Metastasis
- Polyps
- Adenomatous Polyps
Pathways
- Protein Glycosylation
- Glycosylation
- Localization
PTMs
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GALNT12
bosterbio.com/bosterbio-gene-info-cards/GALNT12
References
PMID: 12135769 by Guo J.-M., et al. Molecular cloning and characterization of a novel member of the UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp- GalNAc-T12(1).
PMID: 19617566 by Guda K., et al. Inactivating germ-line and somatic mutations in polypeptide N- acetylgalactosaminyltransferase 12 in human colon cancers.