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- Table of Contents
GAS2 Antibodies
AND GAS2 ELISA kits, GAS2 Proteins
Many biological assays use antibodies to detect GAS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GAS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GAS2 antibodies...
Designing a Western blot for GAS2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GAS2 Western Blot GuideGAS2 Infographic by Boster Bio
All GAS2 Products
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GAS2 Overview
Facts about Growth arrest-specific protein 2.
Growth arrest-specific protein 2 (GAS2)
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells.
May be involved in the membrane ruffling procedure (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | GAS2 |
| Uniprot: | O43903 |
| Entrez: | 2620 |
Family
| Belongs to: |
|---|
| GAS2 family |
Alternative Names
GAS-2; growth arrest-specific 2; growth arrest-specific protein 2; MGC32610
Molecular Weight
Mass (kDA):
34.945 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p14.3 |
| Sequence: | 11; NC_000011.10 (22627758..22885930) |
Tissue Specificity
Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.
Subcellular Localizations
Cytoplasm, cytoskeleton, stress fiber. Membrane; Peripheral membrane protein. Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles.
Diseases
- Growth Arrest
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Neoplasms
- Mammary Neoplasms
- Tissue Adhesions
- Myeloid Leukemia, Chronic
- Myeloid Leukemia
- Prostatic Neoplasms
- Nervousness
- Infective Disorder
- Malignant Neoplasm Of Prostate
Pathways
- Cell Cycle
- Cell Death
- Cell Wall Assembly
- Spore Wall Assembly
- Germination
- Virulence
- Sporulation
- Cell Growth
- Cell Adhesion
- Cell Division
- Oncogenesis
- Pathogenesis
- Gene Silencing
PTMs
- Cleavage
- Phosphorylation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GAS2
bosterbio.com/bosterbio-gene-info-cards/GAS2
References
PMID: 9521882 by Collavin L., et al. cDNA characterization and chromosome mapping of the human GAS2 gene.
PMID: 24706950 by Stroud M.J., et al. GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins.