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GTP cyclohydrolase 1 Antibodies
AND GCH1 ELISA kits, GTP cyclohydrolase 1 Proteins
Many biological assays use antibodies to detect GTP cyclohydrolase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GTP cyclohydrolase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GTP cyclohydrolase 1 antibodies...
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GCH1 Infographic by Boster Bio
All GCH1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M01210
100 µl
Cat # M01210
100 µl
GCH1 Overview
Facts about GTP cyclohydrolase 1.
GTP cyclohydrolase 1 (GCH1)
Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis.
May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the possible function of the enzymatically inactive isoforms remains unknown.
Gene Information
| Human | |
|---|---|
| Gene Name: | GCH1 |
| Uniprot: | P30793 |
| Entrez: | 2643 |
Family
| Belongs to: |
|---|
| GTP cyclohydrolase I family |
Alternative Names
dystonia 14; DYT14; DYT5; DYT5a; DYT5EC 3.5.4.16; GCH; GCH1; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTPCH1; GTP-CH-1; GTP-CH-I; guanosine 5'-triphosphate cyclohydrolase I; HPABH4B
Molecular Weight
Mass (kDA):
27.903 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q22.2 |
| Sequence: | 14; NC_000014.9 (54842005..54902826, complement) |
Tissue Specificity
In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Dystonia Disorders
- Pain
- Parkinson Disease
- Secondary Parkinson Disease
- Movement Disorders
- Chronic Pain
- Hyperphenylalaninemia
- Neurodegenerative Disorders
- Dystonia, Primary
- Malignant Neoplasms
- Inflammation
- Gtp Cyclohydrolase I Deficiency
- Neuralgia
Interacting Proteins
- AHSA1
- YWHAZ
Pathways
- Translation
- Pathogenesis
- Hypersensitivity
- Transport
- Cell Death
- Protein Transport
- Sensitization
- Excretion
- Cell Proliferation
- Gene Silencing
- Catecholamine Secretion
- Biofilm Formation
- Brain Development
PTMs
- Phosphorylation
- Ubiquitination
- Nitrosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GCH1
bosterbio.com/bosterbio-gene-info-cards/GCH1
References
PMID: 1520321 by Togari A., et al. Multiple mRNA forms of human GTP cyclohydrolase I.
PMID: 8068008 by Guetlich M., et al. Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme.