GCHFR Antibodies

AND GCHFR ELISA kits, GCHFR Proteins

Many biological assays use antibodies to detect GCHFR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GCHFR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GCHFR antibodies...

We validate the specificity of these antibodies to GCHFR by testing them on tissues known to express GCHFR positively and negatively. Browse below to find the GCHFR antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for GCHFR? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the GCHFR Western Blot Guide

GCHFR Infographic by Boster Bio

All GCHFR Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-GCHFR Antibody Picoband®

Western blot analysis of GCHFR using anti-GCHFR antibody (A08185-3)

IHC analysis of GCHFR using anti-GCHFR antibody (A08185-3)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A08185-3
100 μg/vial

GCHFR (NM_005258) Human Over-expression Lysate

Human

$628
Cat # LS002644
20 µg, 100 µg

Anti-GCHFR Antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using GCHFR Antibody

Human, Rat

ELISA, IF, IHC, ICC

$335
Cat # A30708
100ul

Human GCHFR Recombinant Protein

SDS-PAGE

$250
Cat # PROTP30047
Starting from 20ug

GCHFR Overview

Facts about GTP cyclohydrolase 1 feedback regulatory protein.

GCHFR 3D structure. Source: alphafold

GTP cyclohydrolase 1 feedback regulatory protein (GCHFR)

Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.

Gene Information

Human
Gene Name:	GCHFR
Uniprot:	P30047
Entrez:	2644

Family

Belongs to:

GFRP family

Alternative Names

GCHFR; GFRP; GFRPP35; GTP cyclohydrolase I feedback regulator; GTP cyclohydrolase I feedback regulatory proteinGTP cyclohydrolase 1 feedback regulatory protein; HsT16933; MGC138467; MGC138469; p35

Molecular Weight

Mass (kDA):
9.698 kDA

Genomic Context


Human

Location:	15q15.1
Sequence:	15; NC_000015.10 (40764068..40767708)

Tissue Specificity

In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).

Subcellular Localizations

Nucleus. Nucleus membrane. Cytoplasm, cytosol.

Diseases

Myocardial Ischemia
Malnutrition
Mood Disorders
Septic Shock
Dyskinetic Syndrome
Psychomotor Disorders
Pathologic Vasoconstriction
Muscle Spasticity
Microcephaly
Decalcification, Pathologic
Dystonia Disorders

Nervous System Disorder
Schizophrenia
Neurotoxicity Syndromes
Pathological Dilatation
Atherosclerosis

Pathways

Translation
Localization

PTMs

Hydroxylation

Oxidation

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GCHFR

References

PMID: 1286669 by Hochstrasser D.F., et al. Human liver protein map: a reference database established by microsequencing and gel comparison.

PMID: 16778797 by Chavan B., et al. GTP cyclohydrolase feedback regulatory protein controls cofactor 6- tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes.