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- Table of Contents
Facts about ADP-ribosylation factor-binding protein GGA2.
Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712).
Human | |
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Gene Name: | GGA2 |
Uniprot: | Q9UJY4 |
Entrez: | 23062 |
Belongs to: |
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GGA protein family |
FLJ20966; Gamma-adaptin-related protein 2; golgi associated, gamma adaptin ear containing, ARF binding protein 2; golgi-associated, gamma adaptin ear containing, ARF binding protein 2; Golgi-localized, gamma ear-containing, ARF-binding protein 2; KIAA1080ADP-ribosylation factor-binding protein GGA2; VEAR; VHS domain and ear domain of gamma-adaptin; VHS domain and ear domain-containing protein
Mass (kDA):
67.15 kDA
Human | |
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Location: | 16p12.2 |
Sequence: | 16; NC_000016.10 (23463542..23510494, complement) |
Ubiquitously expressed.
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein.
PMID: 10749927 by Boman A.L., et al. A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi.
PMID: 10747088 by Hirst J., et al. A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome.