GJB2 Antibodies

AND GJB2 ELISA kits, GJB2 Proteins

Many biological assays use antibodies to detect GJB2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GJB2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GJB2 antibodies...

We validate the specificity of these antibodies to GJB2 by testing them on tissues known to express GJB2 positively and negatively. Browse below to find the GJB2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GJB2 Infographic by Boster Bio

All GJB2 Products

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Applications

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Anti-Gap junction beta-2 protein GJB2 Antibody Picoband®

5 Q&As

Anti-GJB2 antibody, PA1025, Western blottingWB: Rat Liver Tissue Lysate

Human, Mouse, Rat

$370
Cat # PA1025
100 μg/vial

Anti-GJB2 Antibody Picoband®

Western blot analysis of GJB2 using anti-GJB2 antibody (A00512-1)

Human, Mouse, Rat

ELISA, WB

$370
Cat # A00512-1
100 μg/vial

Anti-GJB2 Antibody Picoband®

2 Citations

Western blot analysis of GJB2 using anti-GJB2 antibody (A00512-2)

Expression and distribution of Cx32, Cx26 and Cx43 in patients with HCC

Flow Cytometry analysis of PC-3 cells using anti-GJB2 antibody (A00512-2)

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # A00512-2
100 μg/vial

GJB2 (NM_004004) Human Over-expression Lysate

Human

$628
Cat # LS002706
20 µg, 100 µg

GJB2 Overview

Facts about Gap junction beta-2 protein.

GJB2 3D structure. Source: alphafold

Gap junction beta-2 protein (GJB2)

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. .

Gene Information

Human
Gene Name:	GJB2
Uniprot:	P29033
Entrez:	2706

Family

Belongs to:

connexin family

Alternative Names

beta 2, 26kD (connexin 26); Connexin 26; CX26; CX26DFNA3; DFNA3; DFNA3A; DFNB1; gap junction protein, beta 2, 26kDa (connexin 26); gap junction protein, beta 2, 26kDa; GJB2; HID; KID; NSRD1; PPK

Molecular Weight

Mass (kDA):
26.215 kDA

Genomic Context


Human

Location:	13q12.11
Sequence:	13; NC_000013.11 (20187470..20192938, complement)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Colocalizes with GJB4 at gap junction plaques in the cochlea.

Diseases

Complete Hearing Loss
Sensorineural Hearing Loss (disorder)
Deafness Congenital
Senter Syndrome
Keratitis
Palmoplantar Keratosis
Deaf Mutism
Ichthyoses
Nodular Sclerosis Classical Hodgkin Lymphoma
Dermatologic Disorders
Hearing Loss, Bilateral

Hearing Problem
Dysplasia
Ectodermal Dysplasia
Mutilating Keratoderma
Pendred's Syndrome
Sensory Disorders

Interacting Proteins

OR1D4

Pathways

Pathogenesis
Transport
Localization
Cell Death
Mating
Cornification
Methylation
Secretion
Protein Transport
Ear Development
Tissue Homeostasis
Gene Silencing
Pigmentation

Inner Ear Development
Translation
Ion Homeostasis
Rna Interference
Auditory Behavior
Cell Adhesion
Protein Targeting

PTMs

Methylation

Phosphorylation

Demethylation

Research Areas

Neuroscience
Sensory Systems

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GJB2

References

PMID: 1324944 by Lee S.W., et al. Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines.

PMID: 11439000 by Hamelmann C., et al. Pattern of connexin 26 (GJB2) mutations causing sensorineural hearing impairment in Ghana.