Anti-Gap junction beta-2 protein GJB2 Antibody
Rabbit IgG polyclonal antibody for Gap junction beta-2 protein(GJB2) detection. Tested with WB in Human;Mouse;Rat.
Anti-Gap junction beta-2 protein GJB2 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
Delta-Like 1, also known as DLK1 is a member of the Notch/Delta/Serrate family of epidermal growth factor (EGF)-like repeat-containing proteins which act as ligands in the Notch signaling pathway. Furthermore, DLK1 has six highly conserved epidermal-growth-factor motifs and it also contains up to ten O-glycosylation and N-glycosylation locations, six of them are differentially glycosylated.
|Product Name||Anti-Gap junction beta-2 protein GJB2 Antibody
See all Connexin 26/GJB2 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for CONNEXIN 26/GJB2 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. CONNEXIN 26/GJB2 information: Molecular Weight: 26215 MW; Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.|
|Cite This Product||Anti-Gap junction beta-2 protein GJB2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1025)|
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|Anti-Gap junction beta-2 protein GJB2 Antibody may replace the following items: sc 130729|sc 28659|sc 7261|sc 7261 R.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human GJB2(1-16aa, MDWGTLQTILGGVNKH), different from the related mouse and rat sequences by two amino acids.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For GJB2 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||2706|
|Species Of This Entry||Human|
|Protein Name||Gap junction beta-2 protein|
|Alternative Names||Connexin 26/GJB2|beta 2, 26kD (connexin 26); Connexin 26; CX26; CX26DFNA3; DFNA3; DFNA3A; DFNB1; gap junction protein, beta 2, 26kDa (connexin 26); gap junction protein, beta 2, 26kDa; GJB2; HID; KID; NSRD1; PPK|
|Post Tranlational Modifications||Methylation; Phosphorylation; Demethylation|
|Subcellular Localization||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Colocalizes with GJB4 at gap junction plaques in the cochlea.|
|Gene Location||13q12.11, on Chromasome 13, gene sequence: NC_000013.11 (20187470..20192938, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For GJB2 (Source: Uniprot.org, NCBI)
|Protein Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|
|Research Areas||Neuroscience; Sensory Systems|
|Related Diseases||Complete Hearing Loss; Sensorineural Hearing Loss (disorder); Deafness Congenital; Senter Syndrome; Keratitis; Palmoplantar Keratosis; Deaf Mutism; Ichthyoses; Nodular Sclerosis Classical Hodgkin Lymphoma; Dermatologic Disorders; Hearing Loss, Bilateral; Hearing Problem; Dysplasia; Ectodermal Dysplasia; Mutilating Keratoderma; Pendred's Syndrome; Sensory Disorders|
|Related Pathways||Pathogenesis; Transport; Localization; Cell Death; Mating; Cornification; Methylation; Secretion; Protein Transport; Ear Development; Tissue Homeostasis; Gene Silencing; Pigmentation; Inner Ear Development; Translation; Ion Homeostasis; Rna Interference; Auditory Behavior; Cell Adhesion; Protein Targeting|
|Background||Connexin26(CX26), also known as GAP junction protein, beta2, GJB2. Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. The 3-prime untranslated region of the CX26 transcript contains a putative mRNA instability sequence. The deduced 226-amino acid protein has a calculated molecular mass of about 26 kD. CX26 shares 92.5% identity with rat Cx26. connexin 26(GJB2) is assigned to human chromosome 13q11-q12 .Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. Connexin 26 gene(GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation.|
|Scientific References||PMID: 1324944 by Lee S.W., et al. Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines.|
PMID: 11439000 by Hamelmann C., et al. Pattern of connexin 26 (GJB2) mutations causing sensorineural hearing impairment in Ghana.
Our Boster Quality Guarantee for Anti-Gap junction beta-2 protein GJB2 Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
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