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Product Info Summary
|Reactive Species:||Human, Mouse, Rat|
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Anti-Gap junction beta-2 protein GJB2 Antibody
Boster Bio Anti-Gap junction beta-2 protein GJB2 Antibody catalog # PA1025. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Gap junction beta-2 protein GJB2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1025)
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
A synthetic peptide corresponding to a sequence at the N-terminus of human GJB2 (1-16aa, MDWGTLQTILGGVNKH), different from the related mouse and rat sequences by one amino acid.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
No cross reactivity with other proteins
PA1025 is reactive to GJB2 in Human, Mouse, Rat
PA1025 is guaranteed for WB Boster Guarantee
Background of Connexin 26/GJB2
Connexin26 (CX26), also known as GAP junction protein, beta2, GJB2. Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. The 3-prime untranslated region of the CX26 transcript contains a putative mRNA instability sequence. The deduced 226-amino acid protein has a calculated molecular mass of about 26 kD. CX26 shares 92.5% identity with rat Cx26. connexin 26 (GJB2) is assigned to human chromosome 13q11-q12 .Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. Connexin 26 gene (GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation.
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.
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Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
Validation Images & Assay Conditions
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Anti-GJB2 antibody, PA1025, Western blotting
WB: Rat Liver Tissue Lysate
Gene/Protein Information For GJB2 (Source: Uniprot.Org, NCBI)
Gap junction beta-2 protein
beta 2, 26kD (connexin 26); Connexin 26; CX26; CX26DFNA3; DFNA3; DFNA3A; DFNB1; gap junction protein, beta 2, 26kDa (connexin 26); gap junction protein, beta 2, 26kDa; GJB2; HID; KID; NSRD1; PPK GJB2 BAPS, CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, HID, KID, NSRD1, PPK gap junction protein beta 2 gap junction beta-2 protein|connexin 26|gap junction beta 2 proteinc|gap junction protein, beta 2, 26kDa|mutant gap junction beta 2 protein|mutant gap junction protein beta 2*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
For more info on GJB2, check out the GJB2 Infographic
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In this infographic you will see the following information for GJB2: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]
No publications found for PA1025
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