GNA13 Antibodies

AND GNA13 ELISA kits, GNA13 Proteins

Many biological assays use antibodies to detect GNA13, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GNA13 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GNA13 antibodies...

We validate the specificity of these antibodies to GNA13 by testing them on tissues known to express GNA13 positively and negatively. Browse below to find the GNA13 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GNA13 Infographic by Boster Bio

All GNA13 Products

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Specificity

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Anti-GNA13 Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A04160
100ul

Anti-GNA13 Rabbit Monoclonal Antibody

Western blot analysis of GNA13 expression in HepG2 cell lysate

Human

IHC, WB

$370
Cat # M04160
100 μl/vial

GNA13 Overview

Facts about Guanine nucleotide-binding protein subunit alpha-13.

GNA13 3D structure. Source: alphafold

Guanine nucleotide-binding protein subunit alpha-13 (GNA13)

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866).

GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by sparking RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452).

Gene Information

Human
Gene Name:	GNA13
Uniprot:	Q14344
Entrez:	10672

Family

Belongs to:

G-alpha family

Alternative Names

G alpha-13; G13; G-protein subunit alpha-13; guanine nucleotide binding protein (G protein), alpha 13; guanine nucleotide-binding protein subunit alpha-13; MGC46138

Molecular Weight

Mass (kDA):
44.05 kDA

Genomic Context


Human

Location:	17q24.1
Sequence:	17; NC_000017.11 (65009289..65056740, complement)

Tissue Specificity

Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level).

Subcellular Localizations

Cell membrane; Lipid-anchor. Melanosome. Cytoplasm. Nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (PubMed:18703424). In round spermatids, also present in the nuclei (PubMed:18703424).