Guanine nucleotide-binding protein G(t) subunit alpha-1 (GNAT1)

Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception from the retina (PubMed:22190596).

Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an energetic, GTP-bound state and an inactive, GDP-bound state.