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Facts about Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.
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Human | |
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Gene Name: | GNB1 |
Uniprot: | P62873 |
Entrez: | 2782 |
Belongs to: |
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WD repeat G protein beta family |
beta subunit, signal-transducing proteins GS/GI; G protein, beta-1 subunit; guanine nucleotide binding protein (G protein), beta polypeptide 1; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Transducin beta chain 1
Mass (kDA):
37.377 kDA
Human | |
---|---|
Location: | 1p36.33 |
Sequence: | 1; NC_000001.11 (1785285..1891117, complement) |
The GNB1 Marker is a human protein that is expressed in E.coli. It is characterized by its His-Tag and one-340 aa sequence domain. The product is available in denatured or SDS-PAGE form. The GNB1 marker is stable when stored at 2degC to 8degC for one week. It is stable in -20degC to -80degC, but repeated freeze-thai cycles should be avoided. Besides, first reviewers are given product credits, which is a privilege to all scientists around the world.
When it comes to antibody manufacturing, Boster Bio has an impressive list of benefits. Their immunohistochemistry expertise and pathology focus are ideal for research purposes. Additionally, they offer fast turnaround times, high throughput screening of data, and result confirmation. Their multiplex IHC services enable rapid, cost-effective result archiving, and they can provide assays that detect multiple targets. In addition, Boster Bio's service offerings are unparalleled in the industry, with over 5,000 published articles based on IHC results.
Secondary antibodies, in particular, target CH2 and CH3 domains of immunoglobulins. These antibodies can also be used to study Fc fragments of immunoglobulins, which can serve as therapeutic antibody fragments. Boster Bio also provides IHC services and accepts smear slides from its customers. Moreover, their research antibodies are highly sensitive, with picogram level sensitivity.
High-connectivity DEPs in Boston Bio are gene expression profiling tools that provide information on the structure and functional characteristics of the human genome. They can be used to analyze the interaction between two genes that express a similar protein. The results of this study are the first to demonstrate that these high-connectivity DEPs are functionally active. However, they also require the use of additional tools, such as statistical analysis, to fully understand their phenotypic impact.
Recombinant human GNB1 protein can be used in a wide range of research studies. This protein has been expressed in E. coli by using a cDNA sequence containing the GNB1 gene. Purity of the product is above 85.0%, but testing for endotoxin levels is recommended prior to use in cell culture. The supplier can arrange for testing upon request. The GNB1 solution contains 20mM Tris-HCl buffer, 0.4M Urea and 10% glycerol.
The name of the gene is GNB1; this acronym stands for 'G protein subunit beta 1'. The GNB1 protein contains 340 residues and a mass of 37.4 kDa. It is classified as a transducer and modulator and has orthologs in the mouse, rat, guinea pig, and porcine genomes.
Recombinant human GNB1 from Boster Bio is the highest quality protein available for research applications. Boster Bio also develops ELISA kits for detecting a wide range of targets. They can detect biomarkers in cancer, neurosciences, inflammation, and developmental biology. The sensitivity of these reagents is at the picogram level. Boster Bio's immunological reagents are available through the tebu-bio platform.
ELISA is a method that enables researchers to measure very low concentrations of a target protein. This marker is a component of a protein called GNB1. A high-sensitivity ELISA kit detects the GNB1 protein by producing a colored product. It uses clones #1, #2, and #6 of the antibody. High-sensitivity ELISA kits for the GNB1 marker can be used for research and diagnostics.
Hsp70 is a family of heat shock proteins with multiple homologs. These proteins range in size from 66 to 78 kDa. They are related to bacterial DnaK. High-sensitivity ELISA kits for the GNB1 marker can detect high levels of Hsp70. These kits provide results within 4.5 hours. They can help scientists analyze the role of this protein in the body and in diseases.
Detection of this protein in the CSF is useful for early diagnosis of CJD. Because this marker is expressed in neurons, it can also serve as a marker of the condition. However, Western blotting and ELISA for 14-3-3 gamma are not highly sensitive. Despite these limitations, the results of this test have shown that it is an accurate indicator of CJD.
PMID: 3095147 by Codina J., et al. Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical.
PMID: 14512443 by Niu J., et al. G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.