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Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS meeting with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768).
|Sequence:||1; NC_000001.11 (26890488..26900467, complement)|
Expressed in ocular tissues including retinal pigment epithelium, cornea, ciliary muscle and non-pigmented ciliary epithelium. Also expressed in optic nerve, cartilage, skin and lymph node.