G patch domain-containing protein 3 (GPATCH3)

Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it may control neural crest cell migration involved with ocular and craniofacial growth (PubMed:28397860).

Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS meeting with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768).