- Table of Content
Reveals a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). Might be involved in the regulation of food intake and body weight (By similarity).
|G-protein coupled receptor 1 family|
|Sequence:||1; NC_000001.11 (109539872..109545848)|
Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus (PubMed:11690637, PubMed:29226084). Also expressed in testis (PubMed:11690637, PubMed:29226084) and T cells, B cells, and monocyte (PubMed:29226084). Low expression in many other tissues (PubMed:11690637, PubMed:29226084). Widely expressed in the hippocampus (at protein level).
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Colocalizes with ARRB2/beta-arrestin-2 in the endosome (PubMed:28827538).