Probable G-protein coupled receptor 75 (GPR75)

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation.

Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway between the PI3, Akt and MAP kinases. CCL5/RANTES can also modulate insulin secretion by pancreatic islet cells through activation of this receptor.