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Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway between the PI3, Akt and MAP kinases. CCL5/RANTES can also modulate insulin secretion by pancreatic islet cells through activation of this receptor.
|G-protein coupled receptor 1 family|
|Sequence:||2; NC_000002.12 (53852912..53859967, complement)|
Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).
Cell membrane; Multi-pass membrane protein.