Growth factor receptor-bound protein 14 (GRB14)

Adapter protein that modulates coupling of cell surface receptor kinases with particular signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR).

Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.