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Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
|Sequence:||2; NC_000002.12 (164492417..164622959, complement)|
Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
Cytoplasm. Endosome membrane; Peripheral membrane protein. Upon insulin stimulation, translocates to the plasma membrane.