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- Table of Contents
GRB14 Antibodies
AND GRB14 ELISA kits, GRB14 Proteins
Many biological assays use antibodies to detect GRB14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRB14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRB14 antibodies...
Designing a Western blot for GRB14? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GRB14 Western Blot GuideGRB14 Infographic by Boster Bio
All GRB14 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04177-2
100 μg/vial
Cat # A04177-2
100 μg/vial
GRB14 Overview
Facts about Growth factor receptor-bound protein 14.
Growth factor receptor-bound protein 14 (GRB14)
Adapter protein that modulates coupling of cell surface receptor kinases with particular signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR).
Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Gene Information
| Human | |
|---|---|
| Gene Name: | GRB14 |
| Uniprot: | Q14449 |
| Entrez: | 2888 |
Family
| Belongs to: |
|---|
| GRB7/10/14 family |
Alternative Names
Growth factor receptor-bound protein 14
Molecular Weight
Mass (kDA):
60.988 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q24.3 |
| Sequence: | 2; NC_000002.12 (164492417..164622959, complement) |
Tissue Specificity
Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
Subcellular Localizations
Cytoplasm. Endosome membrane; Peripheral membrane protein. Upon insulin stimulation, translocates to the plasma membrane.
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRB14
bosterbio.com/bosterbio-gene-info-cards/GRB14
References
PMID: 8647858 by Daly R.J., et al. Cloning and characterization of GRB14, a novel member of the GRB7 gene family.
PMID: 11726652 by Bereziat V., et al. Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.