Gasdermin-B Antibodies

AND GSDMB ELISA kits, Gasdermin-B Proteins

Many biological assays use antibodies to detect Gasdermin-B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gasdermin-B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gasdermin-B antibodies...

We validate the specificity of these antibodies to Gasdermin-B by testing them on tissues known to express GSDMB positively and negatively. Browse below to find the GSDMB antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GSDMB Infographic by Boster Bio

All GSDMB Products

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Specificity

Applications

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Anti-Gasdermin-B GSDMB Antibody

Western blot analysis of GSDML expression in Hela (A), HT29 (B), HL-60 (C), MDA-MB435 (D) whole cell lysates

Human

ELISA, WB

$405
Cat # A03968
100ul

Gasdermin like (GSDMB) (NM_001042471) Human Over-expression Lysate

Gasdermin like (GSDMB) Human Over-expression Lysates NM_001042471

Human

$628
Cat # LS055876
20 µg, 100 µg

Anti-GSDMB antibody

Human

ELISA, IHC

$370
Cat # A03968-1
100 μl/vial

GSDMB Overview

Facts about Gasdermin-B.

GSDMB 3D structure. Source: alphafold

Gasdermin-B (GSDMB)

The N-terminal moiety boosts pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216).

The physiological relevance of this observation is unknown (Probable). .

Gene Information

Human
Gene Name:	GSDMB
Uniprot:	Q8TAX9
Entrez:	55876

Family

Belongs to:

gasdermin family

Alternative Names

gasdermin B; gasdermin-B; Gasdermin-like protein; gasdermin-like; GSDMLPRO2521

Molecular Weight

Mass (kDA):
46.786 kDA

Genomic Context


Human

Location:	17q21.1
Sequence:	17; NC_000017.11 (39904595..39918650, complement)

Tissue Specificity

In the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytosol. Cell membrane. Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells.

Diseases

Asthma
Childhood Asthma
Malignant Neoplasms
Inflammation
Immediate Hypersensitivity
Stomach Neoplasms
Neoplasms
Autoimmune Diseases
Autoimmune Reaction
Rheumatoid Arthritis
Dysequilibrium Syndrome
Biliary Cirrhosis
Primary Biliary Cirrhosis

Diabetes Mellitus
Arthritis
Diabetes Mellitus, Insulin-dependent
Crohn Disease
Liver Cirrhosis
Dermatitis, Atopic
Dermatitis

Pathways

Secretory Pathway
Protein Splicing
Dna Methylation
Immune Response
Methylation
Flight
Translation
Innate Immune Response
Cell Growth

Pathogenesis
Chromatin Remodeling
Lymphocyte Activation
Secretion

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GSDMB

References

PMID: 11483580 by Yu Y., et al. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.

PMID: 16625320 by Sin H.-S., et al. Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells.