Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)

Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the action of ERF1.

Involved in regulation of mammalian cell growth. Part of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.