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- Table of Contents
GSPT1 Antibodies
AND GSPT1 ELISA kits, GSPT1 Proteins
Many biological assays use antibodies to detect GSPT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GSPT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GSPT1 antibodies...
Designing a Western blot for GSPT1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GSPT1 Western Blot GuideDesigning an IHC experiment for GSPT1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the GSPT1 IHC GuideGSPT1 Infographic by Boster Bio
All GSPT1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A07761-2
100 μg/vial
Cat # A07761-2
100 μg/vial
GSPT1 Overview
Facts about Eukaryotic peptide chain release factor GTP-binding subunit ERF3A.
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the action of ERF1.
Involved in regulation of mammalian cell growth. Part of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Gene Information
| Human | |
|---|---|
| Gene Name: | GSPT1 |
| Uniprot: | P15170 |
| Entrez: | 2935 |
Family
| Belongs to: |
|---|
| TRAFAC class translation factor GTPase superfamily |
Alternative Names
ERF3A; eRF3aFLJ38048; ETF3A; eukaryotic peptide chain release factor GTP-binding subunit ERF3A; Eukaryotic peptide chain release factor subunit 3a; FLJ39067; G1 to S phase transition 1,551G9.2; G1 to S phase transition protein 1 homolog; GST1
Molecular Weight
Mass (kDA):
55.756 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.13 |
| Sequence: | 16; NC_000016.10 (11868128..11916654, complement) |
Diseases
- Malignant Neoplasms
- Neoplasms
- Stomach Neoplasms
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Stomach
- Tumor Progression
- Carcinoma
- Mammary Neoplasms
- Liver Diseases
- Neoplasm Metastasis
- Metastatic Malignant Neoplasm To The Lymph Node
- Non-neoplastic Disorder
Interacting Proteins
- ETF1
- PABPC1
- UPF1
Pathways
- Translation
- Cell Cycle
- S Phase
- Localization
- Methylation
- Cell Proliferation
- Translational Termination
- Gluconeogenesis
- Chromosome Segregation
- Cell Division
- Cytoskeleton Organization
PTMs
- Methylation
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GSPT1
bosterbio.com/bosterbio-gene-info-cards/GSPT1
References
PMID: 2511002 by Hoshino S., et al. A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells.
PMID: 19417104 by Yamashita A., et al. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.