Granzyme M Antibodies

AND GZMM ELISA kits, Granzyme M Proteins

Many biological assays use antibodies to detect Granzyme M, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Granzyme M in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Granzyme M antibodies...

We validate the specificity of these antibodies to Granzyme M by testing them on tissues known to express GZMM positively and negatively. Browse below to find the GZMM antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GZMM Infographic by Boster Bio

All GZMM Products

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Anti-Granzyme M GZMM Antibody

Western blot (WB) analysis of GZMM polyclonal antibody at 1:500 dilution
Line1:Hela whole cell lysate
Line2:PC12 whole cell lysate
Line3:sp20 whole cell lysate

Human, Mouse, Rat

$405
Cat # A08286
100ul

Anti-Granzyme M/GZMM Antibody Picoband®

Western blot analysis of Granzyme M/GZMM using anti-Granzyme M/GZMM antibody (A08286-1)

Mouse

ELISA, WB

$370
Cat # A08286-1
100 μg/vial

Granzyme M (GZMM) (NM_005317) Human Over-expression Lysate

Human

$628
Cat # LS003004
20 µg, 100 µg

Anti-Granzyme M/GZMM Antibody

Human

IHC

$370
Cat # A08286-2
100 μg/vial

GZMM Overview

Facts about Granzyme M.

GZMM 3D structure. Source: alphafold

Granzyme M (GZMM)

Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin.

Promotes caspase activation and subsequent apoptosis of target cells. .

Gene Information

Human
Gene Name:	GZMM
Uniprot:	P51124
Entrez:	3004

Family

Belongs to:

peptidase S1 family

Alternative Names

EC 3.4.21; EC 3.4.21.-; granzyme M (lymphocyte met-ase 1); granzyme M; Hu-Met-1; LMET1; lymphocyte met-ase 1; Met-1 serine protease; MET1met-ase; Met-ase; Natural killer cell granular protease

Molecular Weight

Mass (kDA):
27.545 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (544053..549922)

Tissue Specificity

Highly and constitutively expressed in activated natural killer (NK) cells.

Subcellular Localizations

Secreted. Cytoplasmic granule. Granules of large granular lymphocytes.

Diseases

Neoplasms
Leukemia
Neoplasms, Experimental
Leukemia, T-cell
Enteropathy-associated T-cell Lymphoma
Carcinoma
Septic Shock
Edema
Malignant Neoplasms
Cytomegalovirus Infections
Innate Immune Response
Lymphoma
Mycoses

T-cell Lymphoma
Mycosis Fungoides
Malignant Squamous Cell Neoplasm
Peripheral T-cell Lymphoma
Ki-1+ Anaplastic Large Cell Lymphoma
Angioimmunoblastic Lymphadenopathy
Nose Neoplasms

Pathways

Cell Death
Cytolysis
Proteolysis
Transport
Cell Development
Glycosylation
Dna Repair
Localization
Release Of Cytochrome C From Mitochondria
Reverse Transcription
Cytokine Production

Cellular Localization
Interphase
Exocytosis
Rna Interference
Viral Replication

PTMs

Cleavage
Phosphorylation

Glycosylation
Myristoylation

Research Areas

Adaptive Immunity
Apoptosis
Cancer
Immunology
Innate Immunity

Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GZMM

References

PMID: 8245461 by Smyth M.J., et al. Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells.

PMID: 7713495 by Pilat D., et al. The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3.