This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
GGT1 Antibodies
AND GGT1 ELISA kits, GGT1 Proteins
Many biological assays use antibodies to detect GGT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GGT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GGT1 antibodies...
Designing a Western blot for GGT1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GGT1 Western Blot GuideGGT1 Infographic by Boster Bio
All GGT1 Products
Product
Figures
Specificity
Applications
Price
GGT1 Overview
Facts about Glutathione hydrolase 1 proenzyme.
Glutathione hydrolase 1 proenzyme (GGT1)
Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases.
In the presence of high concentrations of dipeptides and a few amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine source and contributes to maintain intracellular GSH level.
Gene Information
| Human | |
|---|---|
| Gene Name: | GGT1 |
| Uniprot: | P19440 |
| Entrez: | 2678 |
Family
| Belongs to: |
|---|
| gamma-glutamyltransferase family |
Alternative Names
CD224 antigen; CD224; D22S672; D22S732; EC 2.3.2.2; gamma-glutamyl transpeptidase; gamma-glutamyltransferase 1MGC96904; gamma-glutamyltranspeptidase 1; GGT 1; GGTMGC96963; glutamyl transpeptidase; GTG; MGC96892
Molecular Weight
Mass (kDA):
61.41 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q11.23 |
| Sequence: | 22; NC_000022.11 (24583750..24629005) |
Tissue Specificity
Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Liver Diseases
- Malignant Neoplasm Of Breast
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Asthma
- Liver Carcinoma
- Malignant Paraganglionic Neoplasm
- Liver Neoplasms
- Carcinogenesis
- Cardiovascular Diseases
Pathways
- Prenylation
- Localization
- Protein Prenylation
- Transport
- Pathogenesis
- Secretion
- Cell Migration
- Programmed Cell Death
- Induction Of Apoptosis
- Response To Drug
- Protein Farnesylation
- Conjugation
- Senescence
PTMs
- Cleavage
- Prenylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GGT1
bosterbio.com/bosterbio-gene-info-cards/GGT1
References
PMID: 2904146 by Rajpert-De Meyts E., et al. Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.
PMID: 2907498 by Sakamuro D., et al. The primary structure of human gamma-glutamyl transpeptidase.