Gasdermin-A2 Antibodies

AND Gsdma2 ELISA kits, Gasdermin-A2 Proteins

Many biological assays use antibodies to detect Gasdermin-A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gasdermin-A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gasdermin-A2 antibodies...

We validate the specificity of these antibodies to Gasdermin-A2 by testing them on tissues known to express Gsdma2 positively and negatively. Browse below to find the Gsdma2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Gsdma2 Infographic by Boster Bio

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Gsdma2 Overview

Facts about Gasdermin-A2.

Gsdma2 3D structure. Source: alphafold

Gasdermin-A2 (Gsdma2)

May promote pyroptosis. Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate.

Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity.

Gene Information

Mouse
Gene Name:	Gsdma2
Uniprot:	Q32M21
Entrez:	76758

Family

Belongs to:

gasdermin family

Alternative Names

Gasdermin-A2

Molecular Weight

Mass (kDA):
49.844 kDA

Genomic Context


Mouse

Location:	11\|11 D
Sequence:	11;

Tissue Specificity

Expressed in the gastrointestinal tract, specifically from the middle to the upper region of the gastric mucosa in the glandular stomach.

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Gsdma2

References

PMID: 17350798 by Tamura M., et al. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.