Gasdermin-A3 Antibodies

AND Gsdma3 ELISA kits, Gasdermin-A3 Proteins

Many biological assays use antibodies to detect Gasdermin-A3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gasdermin-A3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gasdermin-A3 antibodies...

We validate the specificity of these antibodies to Gasdermin-A3 by testing them on tissues known to express Gsdma3 positively and negatively. Browse below to find the Gsdma3 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: Clec4e

Gsdma3 Infographic by Boster Bio

All Gsdma3 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Gsdma3 Overview

Facts about Gasdermin-A3.

Gsdma3 3D structure. Source: alphafold

Gasdermin-A3 (Gsdma3)

May play a role in the transition from catagen to telogen in the conclusion of hair follicle morphogenesis (PubMed:15475261). May promote pyroptosis (PubMed:26375003, PubMed:27281216).

Upon cleavage in vitro of genetically designed Gsdma3, the published N-terminal moiety binds to membrane inner leaflet lipids, including bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and much more weakly to monophosphorylated phosphatidylinositols. Homooligomerizes inside the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering pyroptosis.

Gene Information

Mouse
Gene Name:	Gsdma3
Uniprot:	Q5Y4Y6
Entrez:	450219

Family

Belongs to:

gasdermin family

Alternative Names

Gasdermin-A3

Molecular Weight

Mass (kDA):
52.02 kDA

Genomic Context


Mouse

Location:	11 D\|11 62.21 cM
Sequence:	11;

Tissue Specificity

Highest levels in skin with weak expression in placenta and testis. Not detected in the gastrointestinal tract. In skin, expressed in postnatal hair follicles and epidermis as well as sebaceous gland basal cells.

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Gsdma3

References

PMID: 15475261 by Runkel F., et al. The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3.

PMID: 17350798 by Tamura M., et al. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.