Gasdermin-D (Gsdmdc1)

Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and risk signals. Manufactured by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in reaction to canonical, in addition to non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26611636, PubMed:26375259, PubMed:26375003, PubMed:27418190, PubMed:27385778, PubMed:27383986).

After cleavage, moves into the plasma membrane where it strongly binds to membrane inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)- bisphosphate, in addition to phosphatidylinositol (3,4,5)- trisphosphate, and more weakly to phosphatidic acid and phosphatidylserine. Homooligomerizes inside the membrane and forms pores of 10 - 15 nanometers (nm) of internal diameter, permitting the release of mature IL1B and triggering pyroptosis.