Histone H2A.V (H2afv)

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes compact and wrap DNA into chromatin, restricting DNA accessibility to the cellular machineries which require DNA as a template.

Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.