HACD1 Antibodies

AND HACD1 ELISA kits, HACD1 Proteins

Many biological assays use antibodies to detect HACD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HACD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HACD1 antibodies...

We validate the specificity of these antibodies to HACD1 by testing them on tissues known to express HACD1 positively and negatively. Browse below to find the HACD1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HACD1 Infographic by Boster Bio

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PTPLA (HACD1) (NM_014241) Human Over-expression Lysate

Human

$628
Cat # LS009200
20 µg, 100 µg

HACD1 Overview

Facts about Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1.

HACD1 3D structure. Source: alphafold

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (HACD1)

Isoform 1: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic procedure, allows the addition of two carbons into the chain of extended - and very long-chain fatty acids/VLCFAs per cycle.

This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the creation of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Gene Information

Human
Gene Name:	HACD1
Uniprot:	B0YJ81
Entrez:	9200

Family

Belongs to:

very long-chain fatty acids dehydratase HACD family

Alternative Names

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1

Molecular Weight

Mass (kDA):
32.388 kDA

Genomic Context


Human

Location:	10p12.33
Sequence:	10; NC_000010.11 (17589032..17617374, complement)

Tissue Specificity

Isoform 1 is highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder. Also detected in gingival fibroblasts, periodontal ligament cells, osteoblasts and cementoblasts (PubMed:11054553, PubMed:22067203). Isoform 2 is specifically expressed by cementoblasts but also detected in periodontal ligament cells, heart, liver and kidney (at protein level) (PubMed:22067203).

Subcellular Localizations

[Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Myopathy, congenital, with fiber-type disproportion (CFTD)

PTMs

Glycoprotein

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HACD1

References

PMID: 11054553 by Li D., et al. Human protein tyrosine phosphatase-like gene: expression profile, genomic structure, and mutation analysis in families with ARVD.

PMID: 10644438 by Uwanogho D.A., et al. Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene.