Hyaluronan synthase 1 Antibodies

AND HAS1 ELISA kits, Hyaluronan synthase 1 Proteins

Many biological assays use antibodies to detect Hyaluronan synthase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hyaluronan synthase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hyaluronan synthase 1 antibodies...

We validate the specificity of these antibodies to Hyaluronan synthase 1 by testing them on tissues known to express HAS1 positively and negatively. Browse below to find the HAS1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Hyaluronan synthase 1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the HAS1 IHC Guide

HAS1 Infographic by Boster Bio

All HAS1 Products

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Applications

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Anti-Hyaluronan synthase 1/HAS1 Antibody Picoband®

2 Citations

IHC analysis of HAS1 using anti-HAS1 antibody (A04784-1)

Human, Mouse, Rat

IF, IHC, ICC, WB

$370
Cat # A04784-1
100 μg/vial

Hyaluronan synthase 1 (HAS1) (NM_001523) Human Over-expression Lysate

Human

$628
Cat # LS003036
20 µg, 100 µg

HAS1 Overview

Facts about Hyaluronan synthase 1.

HAS1 3D structure. Source: alphafold

Hyaluronan synthase 1 (HAS1)

Catalyzes the addition of GlcNAc or GlcUA monosaccharides into the nascent hyaluronan polymer. Therefore, it is vital to hyaluronan synthesis a major part of most extracellular matrices which has a structural function in tissues architectures and regulates cell adhesion, migration and differentiation.

This is one of the isozymes catalyzing which response. Also able to catalyze the synthesis of chito- oligosaccharide based on the substrate (By similarity).

Gene Information

Human
Gene Name:	HAS1
Uniprot:	Q92839
Entrez:	3036

Family

Belongs to:

NodC/HAS family

Alternative Names

HA synthase 1; HAS; huHAS1; hyaluronan synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1

Molecular Weight

Mass (kDA):
64.832 kDA

Genomic Context


Human

Location:	19q13.41
Sequence:	19; NC_000019.10 (51713112..51723991, complement)

Tissue Specificity

Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Headache
Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Carcinoma
Inflammation
Malignant Paraganglionic Neoplasm
Tissue Adhesions
Cell Invasion
Arthritis
Tumor Angiogenesis
Rheumatoid Arthritis

Fibrosis
Cell Transformation, Neoplastic
Atherosclerosis
Neoplasm Invasiveness
Tumor Progression
Hyperplasia
Malignant Neoplasm Of Breast

Interacting Proteins

HAS2
HAS3

Pathways

Secretion
Wound Healing
Cell Migration
Localization
Angiogenesis
Virulence
Cell Growth
Cell Motility
Cell Proliferation
Cell Adhesion
Pathogenesis
Tissue Remodeling
Mrna Transcription

Translation
Mitosis
Oncogenesis
Chondrocyte Differentiation
Parturition
Regeneration
Dedifferentiation

PTMs

Phosphorylation
Biotinylation
Cleavage

Sulphation
Glycosylation
Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HAS1

References

PMID: 8651928 by Itano N., et al. Molecular cloning of human hyaluronan synthase.

PMID: 8798544 by Shyjan A.M., et al. Functional cloning of the cDNA for a human hyaluronan synthase.